NIACINAMIDE

Posted on by Beste Gürkan

What is Niacinamide?

  Niacinamide, also known as Vitamin B3, or Nicotinic Acid, is an agent that provides intercellular communication and has multiple benefits for the skin. To further elucidate the role of the agent providing intercellular communication: One of the most important syntheses at the cellular level is the Krebs (Citric Acid) cycle. Niacinamide is part of a very important coenzyme involved in hydrogen transfer in the Krebs cycle. Nicotinamide adenine dinucleotide (NAD) and Nicotinamide adenine dinucleotide phosphate (NADP) are the most important Niacinamide derivatives.

  Assuming that the skin is protected with a well-formulated broad-spectrum sunscreen (assuming the skin is well protected from sun damage), some studies have proven that Niacinamide improves skin elasticity. It is also known to stabilize and improve the skin barrier function. The most important feature and the most common use is that when skin tone differences in skin tone inequalities are eliminated with Alpha Hydroxy Acids, it can suppress melanin synthesis so that tone differences do not reoccur. In addition, it has been emphasized in some studies that due to the anti-inflammatory effect of Niacinamide on oily and acne-prone skin, it has been observed to relieve these concerns on acne and rosacea-prone skin.

 The benefits of niacinamide for our skin:

 It has been determined that topically (externally) applied Niacinamide increases the rates of ceramide and free fatty acids in the skin. By increasing protein (keratin) synthesis, it helps to increase the level of intercellular NADP.

In this way, it helps to reduce Trans Epidermal Water Loss (TEWL) in the skin and regulate microcirculation in the dermis. Its success in removing skin tone irregularities (spot treatment) is the most popular area of ​​use recently. Its success in removing acne and post-acne spots and redness (which can also be called post-inflammatory hyperpigmentations) is also noteworthy.

It is also an excellent anti-aging active agent, as it smoothes the surface of the skin and inhibits photoaging for people who are concerned about skin wrinkles and various skin damage that occur with aging.

10% Niacinamide Pore Tightening Serum: Contains 10% Niacinamide. Niacinamide: Vitamin B3 is also known as Niacin, Nicotinic Acid or Nicotinamide. The nicotine in cigarettes has no relation or similarity to this vitamin, just a similar name. It is found in the structure of NAD and NADP enzymes in the body and these are the active forms of niacin. Niacin deficiency can cause spotting on the sun-exposed parts of the skin. It is a vitamin that controls the skin's melanin synthesis. It plays an effective role in skin concerns such as pore size, uneven skin tone, acne, redness, fine wrinkles, loss of elasticity. It is also a molecule that plays a major role in reducing the damage to our skin and DNA by free radicals caused by UV rays, environmental pollution, and various irritants such as ethyl alcohol.

Keywords: Skin blemish, blemish treatment, dry skin, dry skin, blemished skin, acne treatment, acne treatment, spotty skin, acne skin, oily skin, wrinkles, Niacinamide, hyperpigmentation

Sources: Nicotinic acid/niacinamide and the skin, W Gehring, Journal of Cosmetic Dermatology, Vol 3, Issue 2, P 88-93, April 2004., Postinflammatory Hyperpigmentation Etiologic and Therapeutic Considerations, Valerie D Callender et al., American Journal of Clinical Dermatology , April 2011, Volume 12, Issue 2, pp 87-99., The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial.Jerajani HR et al., Indian J Dermatol Venereol Leprol . 2010 Jan-Feb;76(1):20-6., Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans , G. Sivapirabu et al., British Journal of Dermatology, Vol 161, Issue 6, P 1357-1365, December 2009., Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage, A. Chiu and AB Kimball, British Journal of Dermatology, Vol. 149, Issue 4, P 681-691, October 2003., Niacinamide: AB Vitamin that Improves Aging Facial Skin Appearance, Donald L. Bissett et al., Dermatologic Surgery, Vol 31, Issue S1, P 860-866, July 2005., Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible, Amanda Greatens et al., Experimental Dermatology, Vol 14, Issue 7, P 498-508, July 2005., In Vivo Modulation of Signaling Factors Involved in Cell Survival, Anirban K. Mitra et al., Journal of Radiation Research (2004) 45 (4): 491-495., Downregulation of NF-κB activation in human keratinocytes by melanogenic inhibitors, Kwang Seok Ahn et al., Journal of Dermatological Science Vol 31, Issue 3, P 193-201, May 2003.

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